ANTI-FUNGAL ACTIVITIES OF ALLIUM SATIVUM AQUEOUS EXTRACT ON IRREFUTABLE DERMATOPHYTES IN BAUCHI STATE, NIGERIA

Abstract

Dermatophytic contagion is a communal infection that creates public health menace. The study was targeted at determining the anti-fungal actions of aqueous garlic extracts on dermatophyte so as to avail natural and cost effective remedy to victims of dermatophytic contagion. The actions of aqueous extracts of garlic (Allium sativum) on dermatophytes were reconnoitered on isolates of these disease causing fungi secluded from one hundred and thirty three patients attending Infectious Disease Hospital Bayara in Bauchi state. Out of the 133 isolates cultured, growths identified to be fungi were observed in only 60 petri dishes. The pattern of the organisms’ response to aqueous extraction was ascertained by the use of disk diffusion technique. The outcomes were matched with the achievements of a customary antifungal medication called Griseofulvin. The isolates encompassed; Trichophyton violeseum, Trichophyton mentagrophytes, Trichophyton tonsurans and Trichophyton rubrum. The effect of the antifungal operations of aqueous garlic extract disclosed high but wide-ranging intensities of antifungal efficacy on the dissimilar species of the dermatophytes at five diverse intensification or application of; 400 mg/ml, 200 mg/ml, 100 mg/ml, 50 mg/ml, and 25mg/ml. Trichophyton violeseum had the maximum susceptibility trailed by Trichophyton mentagrophytes, Trichophyton rubrum, T. tonsurans respectively. Distance regions of inhibition displayed by the extracted concentrate of garlic in opposition to fungal species fluctuated between the minimum mark of 5.50 mm and maximum mark of 36.67 mm. Aqueous Garlic extract showed very good potential as an antifungal agent.